Description
- Abstract:
- Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics are used to treat severe cases of IBD, however they are currently only given through IV/infusion which is cumbersome for the patient. By creating a delivery vehicle for these biologics, the treatment can be delivered orally to create an easier treatment method for the patients as well as target the lower GI tract. There are a few challenges with oral drug delivery, the biggest one being the harsh pH environment of the stomach. In order for the biologics to successfully reach and treat the bowels, they must remain intact throughout the harsh upper GI tract. In this study, double wall polymeric nanoparticle carriers were designed as an oral delivery vehicle that can target the intestines using a pH-sensitive system. Biologics were encapsulated within polymeric nanoparticles comprised of polylactic acid (PLA) and poly(lactic-co-glycolic acid) (PLGA). These nanoparticles were then coated with a bioadhesive and pH sensitive polymer, Poly(butadiene maleic anhydride-co-DOPA) (PBMAD). By coating the nanoparticle with PBMAD, the core was shielded from an acidic environment similar to that in the upper GI tract. When the double-walled particles were placed in more basic pH environments, similar to that in the lower GI tract, the PBMAD dissolved and detached from the nanoparticles leading to a release of the biologics. These studies show a potential a localized release in the intestines. Once optimized, these double-walled nanoparticles could enhance localized delivery and payload to the disease site.
- Notes:
- Thesis (Sc. M.)--Brown University, 2017
Access Conditions
- Rights
- In Copyright
- Restrictions on Use
- Collection is open for research.
Citation
Steranka, Elaine,
"Double Wall Polymeric Nanoparticle Carrier for Sustained Release of Biologics in the Gastrointestinal Tract"
(2017).
Biomedical Engineering Theses and Dissertations.
Brown Digital Repository. Brown University Library.
https://doi.org/10.7301/Z0J101N9
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Biomedical Engineering Theses and Dissertations
Theses and Dissertations for the Biomedical Engineering department....