Oral dosage forms are generally targeting the absorption in the gastrointestinal (GI) tract. For systemic drug delivery, bioavailability of administered drugs is determined by their …
Microplastic pollution of marine environments is a pressing problem for the health of aquatic ecosystems and for global food supply. Many studies have been done …
This paper illustrated the analytical study using PLM, XRD and ATR for the morphology and drug release potential of film casted, first pressed and heat …
Abstract of Characterization of Pressure-Induced Anisotropy in Atactic Polystyrene, by Derek Rott, ScM, Brown University, May 2019 Atactic polystyrene (aPS) is versatile and cheaply synthesized …
Abstract of Characterization of Temperature-Pressure Induced Morphology in High Molecular Weight Poly (Ethylene Oxide) by Sheila Velagapudi, ScM., Brown University, May 2020 The focus of …
Understanding nanoparticle absorption is a critical step to improving drug delivery techniques. Current methods to determine nanoparticle absorption are often complex and involve direct analysis …
Bioadhesion, defined as the phenomena of adherence between natural tissue and synthetic materials, is an important property with relevance in a wide range of biomedical …
Polymeric nanoparticles loaded with insulin is a highly sought-after drug delivery system in the treatment of diabetes mellitus. The goal of this experiment is to …
This work aims to develop a method of using Fourier-Transform Infrared Spectroscopy (FT-IR) for quantification of polymer levels in biological samples, ex vivo. A method …
The overarching goal of this project is to utilize modulated differential scanning calorimetry and hot-stage x-ray diffraction to characterize and quantify the formation of oriented …
Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics …
The degree of interaction between nanoencapsulated material and gastrointestinal mucin can be an important determinant in efficiency of absorption of orally delivered therapeutics. Mucus lining …
When exposed to pressures below and above their glass transition temperature (Tg) and melting temperatures (Tm) over time, both the amorphous and crystalline regions of …
Diabetics will typically take an insulin regimen with fast acting bolus insulin and long acting basal insulin. The most common methods of delivering this insulin …
This paper investigates the impact of processing conditions, specifically temperature and pressure, on inducing mesophase morphologies in Isotactic Polypropylene (iPP). iPP is a highly valued …
This study examines how molecular weight, temperature, pressure, and the addition of the drugs dolutegravir and curcumin affect the mesophase formation of Polyethylene Glycol (PEG) …
This work aimed to identify the morphological effects of heat and pressure on high molecular weight (300,000 kDa) polyethylene oxide, with a specific focus on …
Abstract of Novel Heart Failure Development in Swine, by Jay Budrewicz, ScM., Brown University, May 2017. Objective: There is a need for a simple and …