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Items (1-20) out of 44 results

A NOVEL DUAL-FUNCTION PLATFORM FOR THE TREATMENT OF RECURRENT BACTERIAL VAGINOSIS (BV)

Description:
Bacterial vaginosis (BV) is the most common vaginal condition among reproductive-age women, yet it is often dismissed as a minor nuisance. This misconception ignores the …
Year:
2026
Contributor:
Selamawi, Danait (creator)
Mathiowitz, Edith (Advisor)
Crego, Adam (Reader)
Shukla,, Anita (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
drug delivery
bacterial vaginosis
Collection:
Biology and Medicine
Theses and Dissertations
Biotechnology
Available to Brown-affiliated users only
Full Record

Advanced Polymeric Nanoparticles and Microscopic Approaches to Exploring Particle Uptake Passages in the Gastrointestinal (GI) Tract

Description:
Oral dosage forms are generally targeting the absorption in the gastrointestinal (GI) tract. For systemic drug delivery, bioavailability of administered drugs is determined by their …
Year:
2022
Contributor:
Shin, Hyeseon (creator)
Mathiowitz, Edith (Advisor)
Delaney, Sarah (Reader)
Chen, Ou (Reader)
Shukla, Anita (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
Drug delivery systems
Polymeric nanoparticles
Electron microscopy
Scanning electron microscopy
Gastrointestinal system
Transmission electron microscopy
Collection:
Chemistry
Theses and Dissertations
Full Record

Analysis of Polystyrene Microsphere Uptake in Passively Fed Danio rerio Larvae via FT-IR Spectroscopy and Fluorescence-Based Detection

Description:
Microplastic pollution of marine environments is a pressing problem for the health of aquatic ecosystems and for global food supply. Many studies have been done …
Year:
2021
Contributor:
Maxwell, Tyler (creator)
Mathiowitz, Edith (Advisor)
Creton, Robbert (Reader)
Jong, Yong (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Fluorescence microscopy
Zebra danio
Polymeric nanoparticles
FT-IR
Microplastics
Plastic pollution
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Analytical Study Using PLM, XRD, And ATR On The Morphology And Drug Release Potential Of Film Casted, Cold Pressed, And Heat Pressed Poly (L-lactic acid) And Curcumin

Description:
This paper illustrated the analytical study using PLM, XRD and ATR for the morphology and drug release potential of film casted, first pressed and heat …
Year:
2023
Contributor:
Chen, Zihao (creator)
Mathiowitz, Edith (Advisor)
Schell, Jacquelyn (Reader)
Chen, Qian (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Biotechnology
Biomaterials
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Full Record

Characterization of Pressure-Induced Anisotropy in Atactic Polystyrene

Description:
Abstract of Characterization of Pressure-Induced Anisotropy in Atactic Polystyrene, by Derek Rott, ScM, Brown University, May 2019 Atactic polystyrene (aPS) is versatile and cheaply synthesized …
Year:
2019
Contributor:
Rott, Derek (creator)
Mathiowitz, Edith (Advisor)
Mathiowitz, Edith (Reader)
Shukla, Anita (Reader)
Horrigan, Diana (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Polystyrene
mesophase
hot-pressing
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Characterization Of Temperature-Pressure Induced Morphology in High Molecular Weight Poly (Ethylene Oxide)

Description:
Abstract of Characterization of Temperature-Pressure Induced Morphology in High Molecular Weight Poly (Ethylene Oxide) by Sheila Velagapudi, ScM., Brown University, May 2020 The focus of …
Year:
2020
Contributor:
Velagapudi, Sheila (creator)
Mathiowitz, Edith (Advisor)
Schell, Jacquelyn (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
poly (ethylene oxide)
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Designing a Novel Approach to Quantify Polymeric Nanoparticle Absorption

Description:
Understanding nanoparticle absorption is a critical step to improving drug delivery techniques. Current methods to determine nanoparticle absorption are often complex and involve direct analysis …
Year:
2017
Contributor:
Perez-Rogers, James Christopher (creator)
Mathiowitz, Edith (Advisor)
Morgan, Jeffrey (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Nanoparticles
Oral Drug Delivery
Polymeric nanoparticles
Infrared spectroscopy
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Developing and Implementing dPCR Assays for Standardized Mycoplasma Detection at Tessera Therapeutics

Description:
Introduction: Mycoplasma contaminations in cell culture can influence an experiment's reliability and reproducibility, so it’s vital that cultured cells are frequently tested, usually by commercially …
Year:
2025
Contributor:
Banga, Kitti (creator)
Mathiowitz, Edith (Advisor)
Benczkowski, Matthew (Advisor)
Huang, Eric (Reader)
Darling, Eric (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Mycoplasma
dPCR
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Developing Biologically Relevant Artificial Substrates for Bioadhesive Testing

Description:
Bioadhesion, defined as the phenomena of adherence between natural tissue and synthetic materials, is an important property with relevance in a wide range of biomedical …
Year:
2023
Contributor:
Lyakhovych, Zakhar (creator)
Shukla, Anita (Reader)
Mathiowitz, Edith (Advisor)
Wong, Ian (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymer Films
Polymeric drug delivery systems
Biomedical engineering--Research
Polycaprolactone
Bioadhesion
Curcumin
Chitosan
Ex Vivo
Mucins
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Developing Drug Delivery Systems Using Polyethylene Vinyl Acetate, Loratadine, and a Patent Overlay

Description:
This study examines the morphological and drug-release differences between film cast samples and pressure-processed samples of polyethylene vinyl acetate (EVA) and Loratadine (LAD) matrices. It …
Year:
2025
Contributor:
Shafiei, David (creator)
Mathiowitz, Edith (Advisor)
Morgan, Jeffrey (Reader)
Huang, Eric (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Drug delivery systems
Materials science
Polymer chemistry
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Development and characterization of high loaded polymeric nanoparticles to achieve a controlled basal insulin delivery system in the treatment of Diabetes Mellitus

Description:
Polymeric nanoparticles loaded with insulin is a highly sought-after drug delivery system in the treatment of diabetes mellitus. The goal of this experiment is to …
Year:
2019
Contributor:
Sukhlal, Shiffoni (creator)
Morgan, Jeffrey (Reader)
Mathiowitz, Edith (Advisor)
Schell, Jacquelyn (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Polymers
Diabetes
Drug delivery systems
Polymeric nanoparticles
Insulin
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Development of an Analytical Method for Polymeric Nanoparticle Quantification in Serum by Fourier Transform-Infrared Spectroscopy

Description:
This work aims to develop a method of using Fourier-Transform Infrared Spectroscopy (FT-IR) for quantification of polymer levels in biological samples, ex vivo. A method …
Year:
2019
Contributor:
Nguyen, Travis (creator)
Mathiowitz, Edith (Advisor)
Srivastava, Vikas (Reader)
Furtado, Stacia (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Drug delivery systems
Polymeric nanoparticles
FT-IR
Quantification
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Developments Toward the Characterization and Quantification of Pressure-Temperature Induced Mesophases in Non-Mesogenic Thermoplastic Polymers

Description:
The overarching goal of this project is to utilize modulated differential scanning calorimetry and hot-stage x-ray diffraction to characterize and quantify the formation of oriented …
Year:
2018
Contributor:
Baptista, Cameron (creator)
Mathiowitz, Edith (Advisor)
Tripathi, Anubhav (Reader)
Furtado, Stacia (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Polymer Films
Biomedical engineering
Polymeric drug delivery systems
Biomedical materials
Materials science
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Double Wall Polymeric Nanoparticle Carrier for Sustained Release of Biologics in the Gastrointestinal Tract

Description:
Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics …
Year:
2017
Contributor:
Steranka, Elaine (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Nanoparticles
Drug delivery systems
Polymeric drug delivery systems
Inflammatory bowel diseases
Oral Drug Delivery
Polymeric nanoparticles
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Effect Of Mucin On Hydrodynamic Diameter And Zeta Potential Of Polymeric Nanospheres

Description:
The degree of interaction between nanoencapsulated material and gastrointestinal mucin can be an important determinant in efficiency of absorption of orally delivered therapeutics. Mucus lining …
Year:
2017
Contributor:
Goldenshtein, Victoria (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Tripathi, Anubhav (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Oral Drug Delivery
Polymeric nanoparticles
Biological Barriers
Mucin interaction with nanospheres
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Effects of Pressure on the Morphology of Semi-Crystalline Polymers

Description:
When exposed to pressures below and above their glass transition temperature (Tg) and melting temperatures (Tm) over time, both the amorphous and crystalline regions of …
Year:
2016
Contributor:
Baker, Christopher Michael (creator)
Morgan, Jeffrey (Reader)
Mathiowitz, Edith (Advisor)
Tripathi, Anubhav (Reader)
Darling, Eric (Reader)
Reineke, Joshua (Reader)
Brown University. Biology and Medicine: Artificial Organs, Biomaterials, and Cell Technology (sponsor)
Genre:
theses
Subject:
morphology
Biotechnology
Polymers
Polymer Films
Collection:
Biology and Medicine
Artificial Organs, Biomaterials, and Cell Technology
Theses and Dissertations
Full Record

Effects of Processing and Drug Loading on Morphology and Drug Release in PCL–Rifampicin Systems

Description:
This study examines how processing conditions regulate polymer morphology and mesophase formation in poly(caprolactone) (PCL) and how these structural transitions govern rifampicin release behavior. Demonstrating …
Year:
2026
Contributor:
George, Susan (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Jong, Yong (Reader)
Brown University. Biology and Medicine: Biotechnology (sponsor)
Genre:
theses
Subject:
Drug delivery systems
mesophase
biodegradable polymers
Collection:
Biology and Medicine
Biotechnology
Theses and Dissertations
Full Record

Evaluating the Diffusive Capabilities of Polymeric Nanoparticles in Mucosal Environments

Description:
Oral drug delivery is a preferred route of administration for medication due to convenience and accessibility. However, due to enzymatic degradation in the gastrointestinal (GI) …
Year:
2025
Contributor:
Haque, Hena Mariam (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Shukla, Anita (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Nanoparticles
Oral Drug Delivery
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

EVALUATION OF DIFFUSIVE CAPABILITIES FOR POLYMERIC COATINGS ON POLYSTYRENE NANOPARTICLES THROUGH MUCIN SOLUTIONS

Description:
Orally-administered drugs are the most widely accepted route of administration despite poor dose bioavailability due to enzymatic degradation in the gastrointestinal (GI) tract and mucoadhesion …
Year:
2026
Contributor:
DeSantis, Michael (creator)
Shukla, Anita (Reader)
Horrigan, Diana (Reader)
Mathiowitz, Edith (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymeric drug delivery systems
Oral Drug Delivery
Polymeric nanoparticles
Polyethylene glycol
Gastrointestinal system
Mucins
poly-L-lysine
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Fourier-transform infrared spectroscopy for detection and quantification of polymer nano-particles

Description:
Oral delivery of biologics is an extremely researched topic due to its possible benefits. One of the common ways to achieving this goal is by …
Year:
2019
Contributor:
Milovanovic, Kosta (creator)
Mathiowitz, Edith (Advisor)
Furtado, Stacia (Reader)
Sobieraj, Andrea (Reader)
Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:
theses
Subject:
Nanoparticles
Polymeric drug delivery systems
Fourier transform infrared spectroscopy
Collection:
Biology and Medicine
Molecular Pharmacology, Physiology, and Biotechnology
Theses and Dissertations
Full Record

Items (1-20) out of 44 results