Description
- Abstract:
- Chronic pain is a condition that lacks effective treatment. Nerve injury and inflammation can lead to chronic unrelenting pain in a significant number of individuals. New, non-additive, non-opioid therapies are needed. Voltage gated CaV2.2 calcium channels are essential for mediating noxious signals that are perceived as pain, and they also contribute to pathological pain. Inhibitors of CaV2.2 calcium channels are effective analgesics but their use in the clinic has so far been limited to intrathecal application. Here we assess the function of CaV2.2 channels at nociceptor nerve endings in skin. We ask if peripheral CaV2.2 channels have a role in neurogenic hyperalgesia.
- Notes:
- Scholarly concentration: Non-Scholarly Concentrator
Access Conditions
- Use and Reproduction
- All rights reserved
Citation
Li, Daniel, Soto Lopez, E Javier, DuBreuil, Daniel, et al.,
"Inhibition of Voltage-Gated CaV2.2 Calcium Channels in Peripheral Nociceptor Nerve Endings Prevents Neurogenic Hyperalgesia in Mice"
(2019).
Warren Alpert Medical School Academic Symposium.
Brown Digital Repository. Brown University Library.
https://repository.library.brown.edu/studio/item/bdr:957204/
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Warren Alpert Medical School Academic Symposium
The Warren Alpert Medical School Academic Symposium is an annual event at Warren Alpert Medical School of Brown University that provides Year II medical students a venue to present their summer research in a poster format. Participation in the Symposium …...