All disciplines of biomedical research utilize in vitro models to answer a range of biological questions. Traditional in vitro models, two-dimensional (2D) cell monolayers, fail …
Tendon and ligament injuries display poor healing capacities from the formation of scar-like tissue resulting in decreased mechanical properties. The application of biomechanics, the study …
Recent advancements in the techniques used for developing in vitro three-dimensional cell cultures, such as bioprinting or microtissue formation, has offered a more accurate representation …
Carbon nanomaterials are under development for diverse commercial applications ranging from conductive films to oil dispersants. Either through intended use or accidental release, the potential …
Human tissue regeneration is often characterized by the over-deposition of collagen, resulting in fibrotic scarring. Traditional research into wound healing and fibrosis relies heavily on …
Abstract of Human Cell-Based In Vitro Toxicity Testing Landscape: Market Analysis and Trends Report, by Megan Marie Grant, Master of Science, Brown University, May 2020. …
Synthesis and degradation of the extracellular matrix (ECM) are important for tissue development, morphogenesis, repair, and remodeling. Multiple proteinases are involved in the degradation of …
The need for tissues and organs presents a complex problem for our society that can be potentially resolved through bioengineering. Thus, there is an extensive …
Fibrosis occurs when the production of cross-linked collagen fibrils exceeds their degradation [1]. While there are multiple potential triggering stimuli and contributing factors to fibrotic …
Due to the global burden of cardiovascular disease, there exists a need for readily available blood vessel replacements that can integrate into the patient’s native …
The advancement of three dimensional biological techniques, such as microtissues, allows for the more accurate representation of in vivo structures. Yet, the added dimension pushes …
Microtissue self-assembly and fusion are biological processes that are important to the fields of tissue engineering and biofabrication and particularly relevant to techniques such as …
Skeletal muscle in vitro models have traditionally utilized mammalian cell lines isolated from rat or mouse skeletal muscles. These models have been extensively validated in …
Fibrosis is a multifactorial process characterized by the excessive accumulation of extracellular matrix (ECM), increased tissue stiffness, and decreased elasticity. To understand how growth factor …
In this research, two inhibitors of MMPs were added to dermal fibroblast tissue rings that were allowed to self-assemble and produce their own ECM. One …
Standard toxicity testing of chemicals to assess risk in humans is commonly done on animals. The problem, however, is that animals have been found to …
While many strides have been made in the field of tissue engineering since its inception, the need for a physiologically relevant biological substitute remains unmet. …