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Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

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Items (1-20) out of 24 results

A Non-Invasive Retinal Prosthesis Using Near-Infrared Photothermal Stimulation: From System Design to Cortical Signal Validation

Description:
In this study, a non-contact retinal prosthesis system based on gold nanorod (AuNR)-enhanced near-infrared photothermal stimulation was designed and verified. Based on previous research, the …
Year:
2025
Contributor:
Li, Jinqian (creator)
Lee, Jonghwan (Advisor)
Srivastava, Vikas (Reader)
Gray, Marissa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
retinal prosthetics
near infrared stimulation
gold nanorods
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Abstract of Developing an Anti-Hyphal Liposome Delivery System to Mitigate Candida albicans Pathogenicity in Vulvovaginal Candidiasis, by Jack Blocker, Sc.M, Brown University, May 2026

Description:
Vulvovaginal candidiasis (VVC), caused predominantly by the opportunistic fungal pathogen Candida albicans, affects approximately 75% of women in their lifetime, and a substantial subset experience …
Year:
2026
Contributor:
Blocker, Jack Howard (creator)
Shukla, Anita (Advisor)
Srivastava, Vikas (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Candida albicans
Hydrogel
Liposomes
antifungal biomaterials
Biomaterials
Antibiofilm activity
Azoles
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Architectural Basis for Lingual Soft Tissue Mechanics

Description:
The mammalian tongue consists of a complex array of intersecting muscular components with the capacity to create an extraordinary array of functional geometries and deformations …
Year:
2022
Contributor:
Leichter, Dana M (creator)
Gilbert, Richard (Advisor)
Srivastava, Vikas (Reader)
Mathiowitz, Edith (Reader)
Nicosia, Mark (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
bioimaging
Finite element method
Computational modeling
Diffusion MRI
Lingual Biomechanics
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Artificial Intelligence for Sleep Apnea Detection and Prediction from Electrocardiograms

Description:
Sleep apnea is a common, yet underdiagnosed, sleep-related breathing disorder associated with increased risk of cardiovascular issues. This work uses a multifaceted approach integrating artificial …
Year:
2024
Contributor:
Gatsonis, Achilles Nicholas (creator)
Karniadakis, George (Advisor)
Chu, Antony (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Machine Learning
Obstructive Sleep Apnea
Artificial intelligence
Deep Learning
Electrocardiographs
Apnea
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Characterization Of Temperature-Pressure Induced Morphology in High Molecular Weight Poly (Ethylene Oxide)

Description:
Abstract of Characterization of Temperature-Pressure Induced Morphology in High Molecular Weight Poly (Ethylene Oxide) by Sheila Velagapudi, ScM., Brown University, May 2020 The focus of …
Year:
2020
Contributor:
Velagapudi, Sheila (creator)
Mathiowitz, Edith (Advisor)
Schell, Jacquelyn (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
poly (ethylene oxide)
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Collective and Individual Invasion of Multicellular Spheroids in 3D Matrix

Description:
The epithelial-mesenchymal transition (EMT) is associated with solid tumor dissemination and metastasis. Directed migration of tumor cells into the surrounding stroma occurs through both collective …
Year:
2023
Contributor:
Marzoratti, Alejandro M (creator)
Wong, Ian (Advisor)
Srivastava, Vikas (Reader)
Lawler, Sean (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
cancer cell invasion
epithelial mesenchymal transition
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Engineering a Cell-targeted Therapy for Neovascularization in Ischemic Cardiac Tissue

Description:
Ischemic heart disease (IHD) is a global health burden responsible for the death of millions of people each year. The primary mechanism that drives myocardial …
Year:
2023
Contributor:
Minor, Alicia (creator)
Coulombe, Kareen (Advisor)
Srivastava, Vikas (Reader)
Shukla, Anita (Reader)
Harrington, Elizabeth (Reader)
Peirce-Cottler, Shayn (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
cardiac myocytes
induced pluripotent stem cells
Experimental design
engineered tissue
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

EXPLORATORY STUDIES AND ALGORITHM DEVELOPMENT TO INVESTIGATE GIANT CANCER CELLS’ CONTRIBUTIONS TO THE TUMOR MICROENVIRONMENT

Description:
Presently, fibrosis and polyploidal giant cancer cells (PGCCs) have links to tumor onset and progression that are poorly understood; however, disentangling this is vital to …
Year:
2023
Contributor:
Morrison, Braxton (creator)
Srivastava, Vikas (Reader)
Singh, Ritambhara (Reader)
Dawson, Michelle (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Breast Cancer
ovarian cancer
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Harnessing Biotransport Phenomena to Simplify Workflow for Clinical Metabolomics using Microsamples

Description:
Despite the existence of metabolomics as a field for nearly two decades, challenges of sample preparation limit the large-scale application and throughput of targeted metabolomics …
Year:
2024
Contributor:
Fariha, Ramisa (creator)
Tripathi, Anubhav (Advisor)
Srivastava, Vikas (Reader)
Mathiowitz, Edith (Reader)
Marshall, John (Reader)
Haass-Koffler, Carolina L. (Reader)
Kingon, Angus (Reader)
Thomas, Stefani (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Pediatrics
Mass spectrometry
Drug abuse
Neonatal Opiod Withdrawal Syndrome
blood diagnostics
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Insights into Pressure-Temperature Induced Morphology and Mesophase Formation in the Non-Mesogenic Polymer Polyethylene Oxide

Description:
This work aimed to identify the morphological effects of heat and pressure on high molecular weight (300,000 kDa) polyethylene oxide, with a specific focus on …
Year:
2021
Contributor:
Clevinger, Tobias B (creator)
Mathiowitz, Edith (Advisor)
Srivastava, Vikas (Reader)
Gray, Marissa (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Biomedical engineering
Biomedical materials
Polyethylene oxide
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Labyrinthine Paths: The In Vivo Analysis of Hyper-Compliant Microcarriers

Description:
Intravenous (IV) drug delivery remains a cornerstone of systemic therapy; however, rapid biological clearance by the liver, spleen, kidneys, and circulating phagocytes significantly limits the …
Year:
2026
Contributor:
Roberts, Sharon Ashley (creator)
Darling, Eric (Advisor)
Mathiowitz, Edith (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Fluorescence
microparticles
drug delivery
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Moving Nanoparticles with Magnets: How Diameter and Composition Affects Magnetophoresis

Description:
The ability to move magnetic particles at a distance through the use of external magnetic fields has broad implications in drug delivery, soft robotics and …
Year:
2021
Contributor:
Aponte, Itzel (creator)
Colvin, Vicki (Advisor)
Srivastava, Vikas (Reader)
Tripathi, Anubhav (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Nanoparticles
Biomedical materials
Magnetophoresis
Magnetic Nanoparticle
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

MULTIMODAL MECHANICAL CHARACTERIZATION AND CONSTITUTIVE MODELING OF SCAFFOLD-FREE, SELF-ASSEMBLED CONNECTIVE RING TISSUES

Description:
Scaffold-free, self-assembled, in vitro tissues hold promise for disease modeling and connective tissue engineering, but their mechanical characterization has been limited to static measures. Energy …
Year:
2026
Contributor:
Nocevski, Nicholas (creator)
Morgan, Jeffrey (Advisor)
Srivastava, Vikas (Reader)
Mathiowitz, Edith (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomedical engineering
Collagen
Viscoelasticity
Materials science
Bioengineering
Fibrosis
Constitutive Modeling
Computational modeling
in vitro
anisotropic materials
Connective tissues
Durability
3D in vitro models
Collagen, SHG, Fiber Organization, Biomedical Engineering, Fluid Mechanics
3D tissue engineering
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Novel Methods in Polymer Drug Delivery

Description:
The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
Year:
2022
Contributor:
Baptista, Cameron (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Tripathi, Anubav (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Polymer Films
Drug delivery systems
Polymeric drug delivery systems
Polymeric nanoparticles
Drug delivery vehicles
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Novel Methods in Polymer Drug Delivery

Description:
The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
Year:
2022
Contributor:
Baptista, Cameron (creator)
Mathiowitz, Edith (Advisor)
Darling, Eric (Reader)
Tripathi, Anubav (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Polymers
Polymer Films
Drug delivery systems
Polymeric drug delivery systems
Oral Drug Delivery
Polymeric nanoparticles
Biomedical materials
Drug delivery vehicles
Drugs--Coatings
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Optimization of Genetic Material Recovery for Downstream Analyses

Description:
The effective detection and analysis of nucleic acids is critical for many fields, including clinical diagnostics, environmental testing and forensic science. Intracellular nucleic acids hold …
Year:
2019
Contributor:
Vimbela, Gina V. (creator)
Tripathi, Anubhav (Advisor)
Morgan, Jeffrey (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
DNA extraction
Point-of-care testing
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Profiling Partial Mesenchymal-Epithelial Transition (MET) states as a function of substrate contacts and MET induction signals

Description:
The epithelial-to-mesenchymal transition (EMT) is associated with weakened cell-cell adhesions that facilitate local invasion during embryonic development, wound healing, and tumor progression. It is believed …
Year:
2026
Contributor:
Vu, Anh Hoang (creator)
Wong, Ian (Advisor)
Srivastava, Vikas (Reader)
Lawler, Sean (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Phenotypic plasticity
mesenchymal-epithelial transition
Cancer cells--Motility
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Quantifying Biomechanical Properties of the Anterior Cruciate Ligament in a Rodent Model

Description:
Objective: Females experience ACL tears at disproportionately higher rates potentially due to the effects of the hormone relaxin. To precisely measure ACL biomechanical properties in …
Year:
2024
Contributor:
Zalk, Samantha Shirley (creator)
Beveridge, Jillian (Advisor)
Fleming, Braden (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Biomechanics
Anterior cruciate ligament
Relaxin
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Quantifying Mechanoreceptors in a Porcine ACL: A Comparative Analysis of Histological Staining Methods

Description:
Anterior cruciate ligament (ACL) injuries account for nearly 50% of all knee injuries, with over 200,000 cases annually in the United States. Centrally located in …
Year:
2025
Contributor:
Kadaba, Amulya (creator)
Fleming, Braden (Advisor)
Beveridge, Jillian (Reader)
Srivastava, Vikas (Reader)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Anterior cruciate ligament
Mechanoreceptors
Histology--Technique
porcine model
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Segmentation of Glioblastoma Images Using Ensembles of Convolutional Neural Networks

Description:
Brain cancer remains a pervasive public health issue. The use of CNN’s to segment brain tumor images has gained significant traction since 2012; however, most …
Year:
2020
Contributor:
Montagut, Julian (creator)
Neretti, Nicola (Reader)
Srivastava, Vikas (Reader)
Lee, Jonghwan (Advisor)
Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:
theses
Subject:
Machine Learning
Histology, Pathological
Artificial intelligence
Glioblastoma
Deep Learning
Image Segmentation
Brain--Cancer
Collection:
Biology and Medicine
Biomedical Engineering
Theses and Dissertations
Full Record

Items (1-20) out of 24 results