Biomedical Engineering Theses and Dissertations

Theses and Dissertations for the Biomedical Engineering department.

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Description:: Understanding nanoparticle absorption is a critical step to improving drug delivery techniques. Current methods to determine nanoparticle absorption are often complex and involve direct analysis …
Year:: 2017
Contributor:: Perez-Rogers, James Christopher (creator); Mathiowitz, Edith (Advisor); Morgan, Jeffrey (Reader); Tripathi, Anubhav (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Nanoparticles; Oral Drug Delivery; Polymeric nanoparticles; Infrared spectroscopy
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics …
Year:: 2017
Contributor:: Steranka, Elaine (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Tripathi, Anubhav (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Nanoparticles; Drug delivery systems; Polymeric drug delivery systems; Inflammatory bowel diseases; Oral Drug Delivery; Polymeric nanoparticles
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: The degree of interaction between nanoencapsulated material and gastrointestinal mucin can be an important determinant in efficiency of absorption of orally delivered therapeutics. Mucus lining …
Year:: 2017
Contributor:: Goldenshtein, Victoria (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Tripathi, Anubhav (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Oral Drug Delivery; Polymeric nanoparticles; Biological Barriers; Mucin interaction with nanospheres
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Orally-administered drugs are the most widely accepted route of administration despite poor dose bioavailability due to enzymatic degradation in the gastrointestinal (GI) tract and mucoadhesion …
Year:: 2026
Contributor:: DeSantis, Michael (creator); Shukla, Anita (Reader); Horrigan, Diana (Reader); Mathiowitz, Edith (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Polymeric drug delivery systems; Oral Drug Delivery; Polymeric nanoparticles; Polyethylene glycol; Gastrointestinal system; Mucins; poly-L-lysine
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: In the last few years, and especially during the COVID-19 pandemic, gene therapy has gained tremendous momentum due to the rapid emergence and large-scale commercial …
Year:: 2025
Contributor:: Knittle, Brendan (creator); Desai, Tejal (Advisor); Mathiowitz, Edith (Reader); Raimondo, Theresa (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Biomedical engineering; Melanoma; Polymeric nanoparticles; Cancer--Immunotherapy; Cancer vaccines; lipid nanoparticles; Drug and gene delivery; mRNA vaccines; Trametinib; Granulocyte-macrophage colony-stimulating factor; Vaccine stability; Nanoengineering; Gene therapy; Vaccines--Design
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
Year:: 2022
Contributor:: Baptista, Cameron (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Tripathi, Anubav (Reader); Srivastava, Vikas (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Polymers; Polymer Films; Drug delivery systems; Polymeric drug delivery systems; Polymeric nanoparticles; Drug delivery vehicles
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
Year:: 2022
Contributor:: Baptista, Cameron (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Tripathi, Anubav (Reader); Srivastava, Vikas (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Polymers; Polymer Films; Drug delivery systems; Polymeric drug delivery systems; Oral Drug Delivery; Polymeric nanoparticles; Biomedical materials; Drug delivery vehicles; Drugs--Coatings
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Description:: Microsphere drug delivery systems still face many hurdles specific to gastrointestinal uptake. Human physiological components are difficult to properly emulate and test without the usage …
Year:: 2021
Contributor:: Jones, Carder Leigh Edward (creator); Mathiowitz, Edith (Advisor); Darling, Eric (Reader); Morgan, Jeffrey (Reader); Schell, Jacquelyn (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Particle Tracking Velocimetry; Biotechnology; Drug delivery systems; Polymeric nanoparticles; diffusion coefficient; Glycoproteins
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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