Description
- Abstract:
- This thesis investigates the optimal product development strategy for Adelle Diagnostics, a neurodiagnostic startup from Brown University developing the Shunt IQ test to predict the efficacy of Normal Pressure Hydrocephalus (NPH) shunt surgery. Amidst a competitive neurodiagnostic landscape and challenging funding environment, the central research question explores the characteristics required for a diagnostic tool to achieve financial success. The study evaluates the hypothesis that focusing on the NPH shunt prediction application, enhancing intellectual property (IP), and pursuing potential licensing offers is the most viable path for Adelle. A mixed-methods approach combined quantitative competitive analysis of 89 startups with qualitative analysis of high-performing outliers and 26 Key Opinion Leader (KOL) interviews guided by I-Corps principles. Statistical analysis revealed patent quantity and employee count as strong predictors of startup valuation and capital raised, supporting the IP-centric hypothesis. Qualitative analysis highlighted higher valuations for companies with diversified portfolios and the risks associated with single-asset pipelines. KOL interviews confirmed a significant unmet need to predict NPH shunt efficacy and a substantial, underdiagnosed NPH market. While enthusiasm exists for biomarker diagnostics, a strong preference for less invasive methods over CSF was noted, though CSF analysis via ShuntIQ may be justifiable pre-shunt. Key recommendations include rigorous clinical validation and robust IP protection for ShuntIQ, prioritizing developing a blood-based assay if feasible, maintaining strategic focus on the NPH indication given market conditions, and actively exploring strategic partnerships. This strategy aims to optimize Adelle's clinical and financial success potential by addressing a clear market need while navigating resource constraints.
- Notes:
- Thesis (Sc. M.)--Brown University, 2025
Citation
Modarres, John Eran,
"Navigating the Normal Pressure Hydrocephalus Landscape: A Product Development Strategy for a Neurodegenerative Diagnostic Startup"
(2025).
Biology and Medicine Theses and Dissertations, Biotechnology.
Brown Digital Repository. Brown University Library.
https://repository.library.brown.edu/studio/item/bdr:2pt3f5q3/
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Biology and Medicine Theses and Dissertations
Theses and Dissertations for the Biology and Medicine department....