Description
- Abstract:
- Trichloroethylene (TCE) is a persistent environmental contaminant that causes male reproductive toxicity. We investigated whether transient increases in TCE exposure modulated male reproductive toxicity by exposing rats via daily oral to repeated gavage exposures (1000 mg/kg/day) and through drinking water (0.6% TCE) for 14 weeks. The gavage route resulted in reversible reduction of epididymis weight, and reduced body weight that persisted for up to 12-weeks after cessation of exposure. Physiologically-based pharmacokinetic modeling predicted that the gavage route results in higher C max and AUC exposure of TCE compared to drinking water exposure, explaining the observed differences in toxicity between dosing regimens.
- Notes:
- This research is supported by the National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program P42ES013660
Access Conditions
- Use and Reproduction
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- Attribution 4.0 International (CC BY 4.0)
Citation
Stermer, Angela R., Klein, David, Wilson, Shelby K., et al.,
"Supplementary material from 'Differential toxicity of water versus gavage exposure to trichloroethylene in rats'"
(2019).
Brown University Open Data Collection, Brown Superfund Data Products, Brown Superfund Project 1: Molecular Biomarkers for Assessing Testicular Toxicity Digital Archive.
Brown Digital Repository. Brown University Library.
https://repository.library.brown.edu/studio/item/bdr:947853/
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Brown University Open Data Collection
This collection contains open and public access data sets created by Brown University faculty and student researchers. Increasingly, publishers and funders are requiring that protocols, data sets, documentation and code underlying publications be retained and preserved in repositories, their locations …... -
Brown Superfund Data Products
This collection contains data sets, code, and documentation files associated with the Brown University Superfund Research Program's investigators and research projects.... -
Brown Superfund Project 1: Molecular Biomarkers for Assessing Testicular Toxicity Digital Archive
This archive is for the long-term preservation and public dissemination of data and digital research products collected and created by researchers associated with Brown University Superfund Research Program Project 1: "Molecular Biomarkers for Assessing Testicular Toxicity". Project Leader: Kim Boekelheide, …...