Description
- Abstract:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global pandemic. In addition to the acute pulmonary symptoms of COVID-19 (the disease associated with SARS-CoV-2 infection), pulmonary and distal coagulopathies have caused morbidity and mortality in many patients. Currently, the molecular pathogenesis underlying COVID-19 associated coagulopathies are under-characterized. While there are many theories for the cause of this pathology, including hyper inflammation and excess tissue damage, the cellular and molecular underpinnings are not yet clear. By analyzing transcriptomic data sets from experimental and clinical research teams, we determined that changes in the transcriptional expression of genes important in the extrinsic coagulation cascade in the lung epithelium may be important triggers for COVID-19 coagulopathy. This study is the first to identify transcriptional changes at the level of the lung epithelium that have the potential to drive the COVID-19 associated coagulopathy. We further found that SARS-CoV-2 patients have significantly elevated levels of epithelial-derived/tissue factor-laden EVs in the bloodstream. Such changes likely induce COVID-19 associated coagulopathies and likely contribute to the systemic and overall pathology of SARS-CoV-2 infection.
- Notes:
- Thesis (Ph. D.)--Brown University, 2022
Citation
FitzGerald, Ethan Samuel,
"The Role of Pulmonary Epithelial Cells in the Induction of COVID-19 Mediated Coagulopathies"
(2022).
Molecular Biology, Cell Biology, and Biochemistry Theses and Dissertations.
Brown Digital Repository. Brown University Library.
https://repository.library.brown.edu/studio/item/bdr:9c4ztak5/
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Molecular Biology, Cell Biology, and Biochemistry Theses and Dissertations
Theses and Dissertations for the Molecular Biology, Cell Biology, and Biochemistry department....